The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis.

Sphingolipids such as ceramides (Cers) play important roles in cell proliferation, apoptosis, and cell cycle regulation. An increased Cer level is linked to the cytotoxic effects of several chemotherapeutics. Various selective cyclooxygenase-2 (COX-2) inhibitors induce anti-proliferative effects in tumor cells. We addressed the possible interaction of the selective COX-2 inhibitors, coxibs, wit...

Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway.

Cyclooxygenase (COX) is a key enzyme of arachidonic acid metabolism and exists as two distinct isoforms. COX-1 is constitutively expressed in most tissues, whereas COX-2 is inducibly expressed at the site of inflammation. Selective inhibitors of COX-2 have been developed and have been used as anti-inflammatory agents. Here, we show that a new-generation COX-2 inhibitor, celecoxib, inhibited exp...

synthesis of 3-(2-(benzyloxy)phenyl)-5-(methylsulfonyl)-4h-1,2,4-triazole as selective cox-2 inhibitor

Celecoxib: a specific COX-2 inhibitor with anticancer properties.

In addition to the well-established pathophysiological role that COX-2 plays in inflammation, recent evidence implies that this isoform may also be involved in multiple biologic events throughout the tumorigenic process. Many epidemiological studies demonstrate that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of a wide range of tumors. Further, COX-2 is chronically overexpress...

synthesis of (1-benzyl-2-(methylsulfonyl)-1h-imidazol-5-yl) methanol as a selective cox-2 inhibitor